Metallochelating liposomes with associated lipophilised norAbuMDP as biocompatible platform for construction of vaccines with recombinant His-tagged 3 antigens: Preparation, structural study and immune response towards rHsp90

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F11%3A00361499" target="_blank" >RIV/68378271:_____/11:00361499 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/11:00361499
Result on the web
<a href="http://dx.doi.org/10.1016/j.jconrel.2011.01.016" target="_blank" >http://dx.doi.org/10.1016/j.jconrel.2011.01.016</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jconrel.2011.01.016" target="_blank" >10.1016/j.jconrel.2011.01.016</a>

Result language
angličtina
Original language name
Metallochelating liposomes with associated lipophilised norAbuMDP as biocompatible platform for construction of vaccines with recombinant His-tagged 3 antigens: Preparation, structural study and immune response towards rHsp90
Original language description
Hsp90-CA is present in cell wall of Candida pseudohyphae or hyphae - typical pathogenic morphotype for 31 both systemic and mucosal Candida infections. Heat shock protein from Candida albicans (hsp90-CA) is an 32 important target for protective antibodies during disseminated candidiasis of experimental mice and human. 33 His-tagged protein rHsp90 was prepared and used as the antigen for preparation of experimental 34 recombinant liposomal vaccine. Nickel-chelating liposomes (the size around 100 nm, PDI0.1) were 35 prepared from the mixture of egg phosphatidyl choline and nickel-chelating lipid DOGS-NTA-Ni (molar ratio 36 95:5%) by hydration of lipid film and extrusion methods. New non-pyrogenic hydrophobised derivative of 37 MDP (C18-O-6-norAbuMDP) wasincorporated into liposomes as adjuvans. by metallochelating bond and the structure of these proteoliposomes 39 was studied by dynamic light scattering, AF microscopy, TEM and GPC.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)