Beta-Cyclodextrin Duplexes That Are Connected through Two Disulfide Bonds: Potent Hosts for the Complexation of Organic Molecules

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F12%3A00383761" target="_blank" >RIV/68378271:_____/12:00383761 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/12:00383761

Result on the web

<a href="http://dx.doi.org/10.1002/chem.201201239" target="_blank" >http://dx.doi.org/10.1002/chem.201201239</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/chem.201201239" target="_blank" >10.1002/chem.201201239</a>

Result language

angličtina

Original language name

Beta-Cyclodextrin Duplexes That Are Connected through Two Disulfide Bonds: Potent Hosts for the Complexation of Organic Molecules

Original language description

New tubular host molecules, which are composed of two beta-cyclodextrin macrocycles that are connected through two disulfide bonds, have been prepared by the air-promoted oxidation of 6I,6IV-dideoxy-6I,6IV-disulfanyl-beta-cyclodextrin in aqueous solution. This reaction leads to three products: monomeric intramolecular disulfide and two dimeric species, which are termed as non-eclipsed and eclipsed cyclodextrin duplexes. Oxidation at a concentration of the starting thiol of 0.1 mM gave the intramoleculardisulfide as the major product whereas a concentration in the millimolar range afforded the dimeric species as the dominant products. The tubular structure of the non-eclipsed isomer was unequivocally determined by X-ray analysis. The binding affinitiesof the duplexes to a wide range of compounds, including fluorescent dyes and clinically used drugs Imatinib and Esomeprazol, were studied in water by ITC. For most guest compounds, the experimentally determined Ka values were in the rang

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CF - Physical chemistry and theoretical chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemistry - A European Journal

ISSN

0947-6539

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

39

Country of publishing house

DE - GERMANY

Number of pages

13

Pages from-to

12292-12304

UT code for WoS article

000308879000018

EID of the result in the Scopus database

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