Charge transfer through DNA/DNA duplexes and DNA/RNA hybrids: complex theoretical and experimental studies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F13%3A00396365" target="_blank" >RIV/68378271:_____/13:00396365 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/13:00396365 RIV/61388963:_____/13:00396365 RIV/00216305:26310/13:PU104535

Result on the web

<a href="http://dx.doi.org/10.1016/j.bpc.2013.07.009" target="_blank" >http://dx.doi.org/10.1016/j.bpc.2013.07.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bpc.2013.07.009" target="_blank" >10.1016/j.bpc.2013.07.009</a>

Result language

angličtina

Original language name

Charge transfer through DNA/DNA duplexes and DNA/RNA hybrids: complex theoretical and experimental studies

Original language description

Oligonucleotides conduct electric charge via various mechanisms and their characterization and understanding is a very important and complicated task. In this work, experimental (temperature dependent steady state fluorescence spectroscopy, time-resolvedfluorescence spectroscopy) and theoretical (Density Functional Theory) approaches were combined to study charge transfer processes in short DNA/DNA and RNA/DNA duplexes with virtually equivalent sequences. The experimental results were consistent with the theoretical model ? the delocalized nature of HOMO orbitals and holes, base stacking, electronic coupling and conformational flexibility formed the conditions for more effective short distance charge transfer processes in RNA/DNAhybrids. RNA/DNA and DNA/DNA charge transfer properties were strongly connectedwith temperature affected structural changes ofmolecular systems?charge transfer could be used as a probe of even tiny changes of molecular structures and settings.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

JJ - Other materials

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biophysical Chemistry

ISSN

0301-4622

e-ISSN

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Volume of the periodical

180-181

Issue of the periodical within the volume

Oct-Nov

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

127-134

UT code for WoS article

000324898700015

EID of the result in the Scopus database

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