Modulation of monocytic leukemia cell function and survival by highgradient magnetic fields and mathematical modeling studies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F14%3A00427673" target="_blank" >RIV/68378271:_____/14:00427673 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.biomaterials.2013.12.098" target="_blank" >http://dx.doi.org/10.1016/j.biomaterials.2013.12.098</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biomaterials.2013.12.098" target="_blank" >10.1016/j.biomaterials.2013.12.098</a>

Result language

angličtina

Original language name

Modulation of monocytic leukemia cell function and survival by highgradient magnetic fields and mathematical modeling studies

Original language description

The influence of spatially modulated high gradient magnetic fields on cellular functions of human THP-1 leukemia cells is studied. We demonstrate that arrays of high-gradient micrometer-sized magnets induce i) cell swelling, ii) prolonged increased ROS production, and iii) inhibit cell proliferation, and iv) elicit apoptosis of THP-1 monocytic leukemia cells in the absence of chemical or biological agents. Mathematical modeling indicates that mechanical stress exerted on the cells by high magnetic gradient forces is responsible for triggering cell swelling and formation of reactive oxygen species followed by apoptosis. We discuss physical aspects of controlling cell functions by focused magnetic gradient forces, i.e. by a noninvasive and nondestructivephysical approach.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10610 - Biophysics

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomaterials

ISSN

0142-9612

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

3164-3171

UT code for WoS article

000332188400003

EID of the result in the Scopus database

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