Static high-gradient magnetic fields affect the functionality of monocytic cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F14%3A00486097" target="_blank" >RIV/68378271:_____/14:00486097 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Static high-gradient magnetic fields affect the functionality of monocytic cells
Original language description
Magnetic fields, different to electric fields, can intrude into deeper layers of tissue, where they could modulate biochemical processes. In this context, we explored the cellular effects of specifically designed high-performance micro-magnet arrays which, in contrast to conventional magnets, generate high-gradient magnetic fields not encountered in the environment. Exposure of monocytic cells to high-gradient magnetic fields of various strength generated by micro-magnet arrays induced cell swelling followed by accumulation of reactive oxygen species (ROS), and inhibition of cell proliferation. High levels of ROS may damage cellular structures and induce apoptosis. Consistently, prolonged exposure of cells to high-gradient magnetic fields induced time-dependent translocation of phosphatidylserine to the outer leaflet of the membrane.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů