Theoretical and experimental study of charge transfer through DNA: impact of mercury mediated T-Hg-T base pair
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F14%3A00432624" target="_blank" >RIV/68378271:_____/14:00432624 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/14:00432624 RIV/00216305:26310/14:PU108952 RIV/00216208:11320/14:10362682 RIV/68407700:21340/14:00363985
Result on the web
<a href="http://dx.doi.org/10.1021/jp501986a" target="_blank" >http://dx.doi.org/10.1021/jp501986a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/jp501986a" target="_blank" >10.1021/jp501986a</a>
Alternative languages
Result language
angličtina
Original language name
Theoretical and experimental study of charge transfer through DNA: impact of mercury mediated T-Hg-T base pair
Original language description
DNA-Hg complexes may play an important role in sensing of DNA defects or in detecting of Hg presence in the environment. A fundamental way of characterizing DNA-Hg complexes is to study the way how the electric charge is transferred through the molecularchain. The main goal of this contribution was to investigate the impact of a mercury metal cation that links two thymine bases in a DNA T-T mismatched base pair (T-Hg-T) on charge transfer through the DNA molecule. We compared the charge transfer efficiencies in standard DNA, DNA with mismatched T-T base pairs and DNA with T-Hg(II)-T base pair. For this purpose we measured the temperature dependence of steady-state fluorescence and UV-VIS of the DNA molecules. The experimental results were confronted with the results obtained employing theoretical DFT methods. Generally, the efficiency of charge transfer was driven by mercury changing the spatial overlap of bases.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Physical Chemistry B
ISSN
1520-6106
e-ISSN
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Volume of the periodical
118
Issue of the periodical within the volume
20
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
5374-5381
UT code for WoS article
000336510300010
EID of the result in the Scopus database
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