The effect of chemical modification of DNA base on binding of HgII and AgI in metal-mediated base pairs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F16%3A00502365" target="_blank" >RIV/68378271:_____/16:00502365 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/16:00466107
Result on the web
<a href="http://dx.doi.org/10.1016/j.ica.2016.03.007" target="_blank" >http://dx.doi.org/10.1016/j.ica.2016.03.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ica.2016.03.007" target="_blank" >10.1016/j.ica.2016.03.007</a>

Result language
angličtina
Original language name
The effect of chemical modification of DNA base on binding of HgII and AgI in metal-mediated base pairs
Original language description
The Gibbs free energy of formation of metallo-base pair was calculated for the base pairs composed of T, U, F, CN, C and I nucleosides and HgII and AgI metals. The stability of Hg-mediated base pairs gradually decreased owing to the F and CN chemical modification of thymine at carbon C5 and owing to the imino to imidazole change of N3 nitrogen atom linked with HgII. The prevalence of AgI-stabilization versus HgII-stabilization was calculated for the metallo-base pairs composed of T, U, F, CN, C and I nucleosides where nucleophilicity of N3 nitrogen atom gradually decreased. The calculated relative stabilizations of metallo-base pairs agreed qualitatively with the increase in melting temperatures measured previously for respective duplexes upon adding HgII and AgI metals.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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