Nanoscale clustering of the neurotrophin receptor TrkB revealed by super-resolution STED microscopy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F17%3A00484737" target="_blank" >RIV/68378271:_____/17:00484737 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/c7nr03454g" target="_blank" >http://dx.doi.org/10.1039/c7nr03454g</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c7nr03454g" target="_blank" >10.1039/c7nr03454g</a>

Result language
angličtina
Original language name
Nanoscale clustering of the neurotrophin receptor TrkB revealed by super-resolution STED microscopy
Original language description
The nanoscale organization of the tropomyosin-related kinase receptor type B (TrkB), a promising therapeutic target for severe neurodegenerative and psychiatric disorders, is examined by stimulated emission depletion (STED) microscopy using the deconvoluted gated STED option. The performed immunofluorescence nanoscopic subdiffraction imaging of the membrane receptor localization reveals that clusters of oligomeric TrkB states and randomly organized nanodomains are formed in the membranes of differentiated human neuroblastoma SH-SY5Y cells, which are studied as an in vitro model of neurodegeneration.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10305 - Fluids and plasma physics (including surface physics)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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