Cell membrane pore formation and change in ion channel activity in high-gradient magnetic fields
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F17%3A00493921" target="_blank" >RIV/68378271:_____/17:00493921 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1109/LMAG.2017.2732361" target="_blank" >http://dx.doi.org/10.1109/LMAG.2017.2732361</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1109/LMAG.2017.2732361" target="_blank" >10.1109/LMAG.2017.2732361</a>
Alternative languages
Result language
angličtina
Original language name
Cell membrane pore formation and change in ion channel activity in high-gradient magnetic fields
Original language description
We examine membrane pores and the channel stability of cells exposed to high-gradient magnetic fields (HGMFs). As an HGMF generates stress and deformation in the cell membrane through magnetic gradient forces, stretchactivated and voltage-gated ion channels are gated by both the effective membrane tension (σ) and the membrane potential (U). By calculating a (σ, U)-phase diagram, we find an unexpected region of stability for the pores in a cell membrane subjected to an HGMF. Within this region, the cell membrane does not lose its integrity and is stable against pore creation by electric and magnetic fields. Our theoretical arguments lead to predictions for changes in membrane ion channel selectivity in cells treated with magnetic fields. Overall, the results demonstrate that HGMFs can be used as a tool to create a specific stress field in a cell to drive its machinery.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10610 - Biophysics
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
IEEE Magnetics Letters
ISSN
1949-307X
e-ISSN
—
Volume of the periodical
8
Issue of the periodical within the volume
Jul
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
—
UT code for WoS article
000408352700001
EID of the result in the Scopus database
2-s2.0-85029165054