Design and fabrication of novel thiourea coordination compounds as potent inhibitors of bacterial growth

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F19%3A00519110" target="_blank" >RIV/68378271:_____/19:00519110 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1038/s41429-019-0147-2" target="_blank" >https://doi.org/10.1038/s41429-019-0147-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41429-019-0147-2" target="_blank" >10.1038/s41429-019-0147-2</a>

Result language
angličtina
Original language name
Design and fabrication of novel thiourea coordination compounds as potent inhibitors of bacterial growth
Original language description
A new thiourea ligand (HL), namely N-(4-chlorophenyl)morpholine-4-carbothioamide and its Co(III), Ni(II) and Ag(I) complexes (1a, 1b and 1c) were synthesized and investigated by Fourier-transform infrared, 1H NMR and UV-visible spectroscopies. The compounds HL and 1c were characterized by single-crystal X-ray crystallography revealing the triclinic space group P1 for both compounds. The inhibitory effect of HL ligand, 1a, 1b, and 1c complexes was investigated with in vitro tests on Gram-positive and Gram-negative bacteria. For the 1c complex, the results showed that the coordination of the HL to Ag(I) ion increased its antibacterial effect especially against E. coli.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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