Microscopic study of zinc oxide molecular biointerface

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F20%3A00537913" target="_blank" >RIV/68378271:_____/20:00537913 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Microscopic study of zinc oxide molecular biointerface

Original language description

We focus on the actual interface between ZnO and biological environment. At first, by using atomic force microscopy (AFM) we have studied adsorption of fetal bovine serum and bovine serum albumin on ZnO plates. Droplets of biomolecular solution were deposited on clean ZnO substrates for 10 minutes, rindsed with demi water, dried with nitrogen. We employed CF4 treated AFM tips to minimize tip contamination by biomolecules during morphology analysis. Compared to our reference, oxidized diamond surfaces, the morphology of molecular layer is similar, however, the binding forces are much stronger on ZnO. We performed atomic scale computing of the ZnO bionterface by force field method to support understanding the above effects and differences. We discuss implications for protein corona on ZnO nanostructures.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Project

<a href="/en/project/GC19-02858J" target="_blank" >GC19-02858J: Charge transfer and microbiological interactions of hybrid metal oxide nanostructures</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů