Maghemite nanoparticles coated by methacrylamide-based polymer for magnetic particle imaging

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00539851" target="_blank" >RIV/68378271:_____/21:00539851 - isvavai.cz</a>

Alternative codes found

RIV/61389013:_____/21:00539851 RIV/00216208:11110/21:10427484 RIV/00216208:11320/21:10427484 RIV/60461373:22340/21:43922106

Result on the web

<a href="https://link.springer.com/article/10.1007/s11051-021-05164-x" target="_blank" >https://link.springer.com/article/10.1007/s11051-021-05164-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11051-021-05164-x" target="_blank" >10.1007/s11051-021-05164-x</a>

Result language

angličtina

Original language name

Maghemite nanoparticles coated by methacrylamide-based polymer for magnetic particle imaging

Original language description

A wise selection of tracers is critical for magnetic particle imaging (MPI). Most of the current tracers are based on superparamagnetic iron oxide nanoparticles (SPIONs) with a suitable coating. We prepared maghemite cores (γ-Fe2O3) by coprecipitation of Fe(II) and Fe(III) salts with ammonium hydroxide followed by oxidation with hydrogen peroxide and stabilization as an anionic (γ-Fe2O3⊖) or cationic colloid (γ-Fe2O3⨁). The cores were coated by poly(N-(2-hydroxypropyl)methacrylamide)-co-N-[2-(hydroxyamino)-2-oxo-ethyl]-2-methyl-prop-2-enamide. The particles were characterized by dynamic light scattering, transmission electron microscopy, X-ray diffraction, Mössbauer spectroscopy, tested in vitro in a field-free point MPI scanner, and compared to nanoparticles prepared by oxidation with sodium hypochlorite and to the commercially available Resovist®. The cores had an average diameter of 8.0 nm (γ-Fe2O3⨁) and 8.7 nm (γ-Fe2O3⊖). The hydrodynamic diameter was 88 nm. Zeta potential values for both positively charged (+52 mV) and negatively charged particles (–60 mV) provided for good colloidal stabilization. Spinel structure of maghemite was confirmed by Mössbauer spectroscopy. The uncoated γ-Fe2O3⨁ particles yielded an MPI signal lower (by 16 %) than Resovist. The coated ones reached 88 % of the Resovist signal. Anionic γ-Fe2O3⊖ particles reached a higher (uncoated particles, by 15 %) or comparable (coated ones) signal relative to Resovist with a substantially lower signal dispersion. Control particles prepared by oxidation with sodium hypochlorite scored the weakest results. To conclude, a suitable size, narrow size distribution, and colloidal stability predispose the synthetized particles for use as a tracer for MPI. The anionic particles provided a higher signal with a lower dispersion than commercial tracers.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

21001 - Nano-materials (production and properties)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

—

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Nanoparticle Research

ISSN

1388-0764

e-ISSN

1572-896X

Volume of the periodical

23

Issue of the periodical within the volume

2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

15

Pages from-to

52

UT code for WoS article

000620932000003

EID of the result in the Scopus database

2-s2.0-85101277773