Low-temperature polymorphs of lacosamide

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00541704" target="_blank" >RIV/68378271:_____/21:00541704 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/21:43922852 RIV/60461373:22340/21:43922852
Result on the web
<a href="https://doi.org/10.1016/j.jcrysgro.2021.126085" target="_blank" >https://doi.org/10.1016/j.jcrysgro.2021.126085</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jcrysgro.2021.126085" target="_blank" >10.1016/j.jcrysgro.2021.126085</a>

Result language
angličtina
Original language name
Low-temperature polymorphs of lacosamide
Original language description
Lacosamide is used in the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Up-todate, only one polymorph has been described. Our aim was to explore the thermal phase behavior of this compound. When heated, no transformations are observed until the melting point. A very different situation is observed, when lacosamide is cooled. With the use of variable-temperature X-ray diffraction, we were able to detect two phase transformations. The crystal structures of the two new polymorphs were determined by single crystal and powder X-ray diffraction.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Project
<a href="/en/project/TJ02000256" target="_blank" >TJ02000256: Improving drug properties using advanced multi-component forms of active substances</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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