Advanced preclinical models for evaluation of drug-induced liver injury – consensus statement by the European drug-induced liver injury network [PRO-EURO-DILI-NET]

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00546144" target="_blank" >RIV/68378271:_____/21:00546144 - isvavai.cz</a>
Result on the web
<a href="http://hdl.handle.net/11104/0322792" target="_blank" >http://hdl.handle.net/11104/0322792</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jhep.2021.06.021" target="_blank" >10.1016/j.jhep.2021.06.021</a>

Result language
angličtina
Original language name
Advanced preclinical models for evaluation of drug-induced liver injury – consensus statement by the European drug-induced liver injury network [PRO-EURO-DILI-NET]
Original language description
Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF) and one of the leading indications for liver transplantation in Western societies. DILI has become a major health issue for which there is a pressing need to find novel and effective therapies. Although significant progress has been made in understanding the molecular mechanisms underlying DILI, our incomplete knowledge of its pathogenesis and inability to predict DILI is largely due to both discordance between human and animal DILI in preclinical drug development and a lack of models that faithfully recapitulate complex pathophysiological features of human DILI. In this expert Consensus Statement, which is endorsed by the European Drug-Induced Liver Injury Network, we aim to facilitate and outline clinically impactful discoveries by detailing the requirements for more realistic human-based systems to assess hepatotoxicity and guide future drug safety testing.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
<a href="/en/project/LTC19040" target="_blank" >LTC19040: Advanced physical methods in hepatotoxicity studies</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)