Zn–0.8Mg–0.2Sr (wt.%) absorbable screws—an in-vivo biocompatibility and degradation pilot study on a rabbit model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00546336" target="_blank" >RIV/68378271:_____/21:00546336 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22310/21:43922708 RIV/00216208:11110/21:10435128 RIV/00064165:_____/21:10435128

Result on the web

<a href="http://hdl.handle.net/11104/0322890" target="_blank" >http://hdl.handle.net/11104/0322890</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ma14123271" target="_blank" >10.3390/ma14123271</a>

Result language

angličtina

Original language name

Zn–0.8Mg–0.2Sr (wt.%) absorbable screws—an in-vivo biocompatibility and degradation pilot study on a rabbit model

Original language description

In this study, we investigated the biocompatibility and degradation rate of an extruded Zn–0.8Mg–0.2Sr (wt.%) alloy on a rabbit model. An alloy screw was implanted into one of the tibiae of New Zealand White rabbits. After 120 days, the animals were euthanized. Evaluation included clinical assessment, microCT, histological examination of implants, analyses of the adjacent bone, and assessment of zinc, magnesium, and strontium in vital organs (liver, kidneys, brain). Only negligible changes of the implant volume and area were observed. The degradation was not connected with gas evolution. The screws were fibrointegrated, partially osseointegrated histologically. We observed no inflammatory reaction or bone resorption. Periosteal apposition and formation of new bone with a regular structure were frequently observed near the implant surface. The histological evaluation of the liver, kidneys, and brain showed no toxic changes. The alloy was safe, biocompatible, and well-tolerated.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20501 - Materials engineering

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Materials

ISSN

1996-1944

e-ISSN

1996-1944

Volume of the periodical

14

Issue of the periodical within the volume

12

Country of publishing house

CH - SWITZERLAND

Number of pages

21

Pages from-to

3271

UT code for WoS article

000666146700001

EID of the result in the Scopus database

2-s2.0-85108584632