A complex evaluation of the in-vivo biocompatibility and degradation of an extruded ZnMgSr absorbable alloy implanted into rabbit bones for 360 days
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00549687" target="_blank" >RIV/68378271:_____/21:00549687 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/21:43922747 RIV/00216208:11110/21:10436178 RIV/00064165:_____/21:10436178
Result on the web
<a href="http://hdl.handle.net/11104/0325631" target="_blank" >http://hdl.handle.net/11104/0325631</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms222413444" target="_blank" >10.3390/ijms222413444</a>
Alternative languages
Result language
angličtina
Original language name
A complex evaluation of the in-vivo biocompatibility and degradation of an extruded ZnMgSr absorbable alloy implanted into rabbit bones for 360 days
Original language description
In this study, we analyzed an extruded Zn-0.8Mg-0.2Sr (wt.%) absorbable/biodegradable alloy on a rabbit model. Screws made of this alloy were implanted into the rabbit tibia. After 120, 240, and 360 days, we tested the toxicity at the site of implantation and also within the vital organs. The results were compared with a control group, implanted with a Ti-based screw and sacrificed after 360 days. The samples were analyzed using X-ray, micro-CT, and a scanning electron microscope. Chemical analysis revealed only small concentrations of zinc, strontium, and magnesium in the liver, kidneys, and brain. Histologically, the alloy was verified to possess very good biocompatibility after 360 days. We did not observe raised levels of Sr, Zn, or Mg in any of the vital organs when compared with the Ti group at 360 days. The material was found to slowly degrade in vivo, forming solid corrosion products on its surface.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
20501 - Materials engineering
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1422-0067
Volume of the periodical
22
Issue of the periodical within the volume
Dec
Country of publishing house
CH - SWITZERLAND
Number of pages
24
Pages from-to
13444
UT code for WoS article
000737886300001
EID of the result in the Scopus database
2-s2.0-85121043397