Protein corona inhibits endosomal escape of functionalized DNA nanostructures in living cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00546722" target="_blank" >RIV/68378271:_____/21:00546722 - isvavai.cz</a>
Alternative codes found
RIV/61388955:_____/21:00546722 RIV/00023001:_____/21:00081714
Result on the web
<a href="https://doi.org/10.1021/acsami.1c14401" target="_blank" >https://doi.org/10.1021/acsami.1c14401</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsami.1c14401" target="_blank" >10.1021/acsami.1c14401</a>

Result language
angličtina
Original language name
Protein corona inhibits endosomal escape of functionalized DNA nanostructures in living cells
Original language description
DNA nanostructures (DNs) can be designed in a controlled and programmable manner, and these structures are increasingly used in a variety of biomedical applications, such as the delivery of therapeutic agents. When exposed to biological liquids, most nanomaterials become covered by a protein corona, which in turn modulates their cellular uptake and the biological response they elicit. However, the interplay between living cells and designed DNs are still not well established. Namely, there are very limited studies that assess protein corona impact on DN biological activity. Here, we analyzed the uptake of functionalized DNs in three distinct hepatic cell lines.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10610 - Biophysics

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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