Explaining dissolution properties of rivaroxaban cocrystals
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F22%3A00558894" target="_blank" >RIV/68378271:_____/22:00558894 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/22:43925026 RIV/60461373:22340/22:43925026 RIV/00064165:_____/22:10448717 RIV/00216208:11110/22:10448717 RIV/00216208:11310/22:10448717
Result on the web
<a href="https://doi.org/10.1016/j.ijpharm.2022.121854" target="_blank" >https://doi.org/10.1016/j.ijpharm.2022.121854</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2022.121854" target="_blank" >10.1016/j.ijpharm.2022.121854</a>
Alternative languages
Result language
angličtina
Original language name
Explaining dissolution properties of rivaroxaban cocrystals
Original language description
The aim of this study was to improve rivaroxaban water-solubility by cocrystal preparation and to understand this process. The screening with water-soluble coformers was performed via both mechanochemical and solutionmediated techniques. Two cocrystals of rivaroxaban with malonic acid and oxalic acid were prepared, and the structure of the cocrystal with oxalic acid was solved. Both cocrystals exhibit improved dissolution properties. The mechanism of the supersaturation maintenance was studied by in-situ Raman spectroscopy. The transformation into rivaroxaban dihydrate was identified as the criti cal step in the improved dissolution properties of both cocrystals. Moreover, the transformation kinetics and solubilization effects of the coformers were identified as responsible for the differences in the dissolution behavior of the cocrystals.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Pharmaceutics
ISSN
0378-5173
e-ISSN
1873-3476
Volume of the periodical
622
Issue of the periodical within the volume
June
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
121854
UT code for WoS article
000812200200005
EID of the result in the Scopus database
2-s2.0-85131129441