Development of the crystallization process for rivaroxaban−oxalic acid cocrystal preparation using a combination of phase diagrams and in situ measurements
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F25%3A00618927" target="_blank" >RIV/68378271:_____/25:00618927 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22340/25:43933251
Result on the web
<a href="https://hdl.handle.net/11104/0365723" target="_blank" >https://hdl.handle.net/11104/0365723</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.oprd.4c00509" target="_blank" >10.1021/acs.oprd.4c00509</a>
Alternative languages
Result language
angličtina
Original language name
Development of the crystallization process for rivaroxaban−oxalic acid cocrystal preparation using a combination of phase diagrams and in situ measurements
Original language description
This study presents the development of the crystallization process for the rivaroxaban−oxalic acid cocrystal. The solvent screening was conducted by means of the crystallization of the cocrystal from a saturated solution of acetone, ethanol, isopropanol, acetonitrile, ethyl acetate, and ethyl formate. Two selected solvents, namely, ethyl formate and acetone, were subjected to ternary phase diagram construction in order to ascertain the system equilibrium and identify the boundaries for pure cocrystal crystallization. The crystallization process was subsequently examined through the utilization of an in situ Raman spectroscopy probe. It was observed that the rate of transformation decreased at higher temperatures, which is most probably due to lower saturation in terms of the cocrystal.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Organic Process Research & Development
ISSN
1083-6160
e-ISSN
1520-586X
Volume of the periodical
29
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
565-573
UT code for WoS article
001399112700001
EID of the result in the Scopus database
2-s2.0-85218410870