Obeticholic acid forms two series of isostructural non-stoichiometric channel solvates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F22%3A00561353" target="_blank" >RIV/68378271:_____/22:00561353 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/22:43925035 RIV/60461373:22340/22:43925035
Result on the web
<a href="https://doi.org/10.1021/acs.cgd.2c00688" target="_blank" >https://doi.org/10.1021/acs.cgd.2c00688</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.cgd.2c00688" target="_blank" >10.1021/acs.cgd.2c00688</a>

Result language
angličtina
Original language name
Obeticholic acid forms two series of isostructural non-stoichiometric channel solvates
Original language description
The aim of this work was to investigate solid forms of an active pharmaceutical substance, obeticholic acid, and to characterize the discovered structures. Obeticholic acid is used to treat primary biliary cholangitis. No crystal structures have been published until now. Our X-ray powder diffraction results revealed that upon crystallization from various solvents, obeticholic acid forms one of two possible forms. Further investigation by thermogravimetric analysis and differential scanning calorimetry showed that the two forms are in fact solvated.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)