Development of a portable hypoxia chamber for ultra-high dose rate laser-driven proton radiobiology applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F22%3A00568030" target="_blank" >RIV/68378271:_____/22:00568030 - isvavai.cz</a>
Result on the web
<a href="https://hdl.handle.net/11104/0339379" target="_blank" >https://hdl.handle.net/11104/0339379</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13014-022-02024-3" target="_blank" >10.1186/s13014-022-02024-3</a>
Alternative languages
Result language
angličtina
Original language name
Development of a portable hypoxia chamber for ultra-high dose rate laser-driven proton radiobiology applications
Original language description
Oxygen measurements showed that our chambers maintained a radiobiological hypoxic environment for at least 45 min and pathological hypoxia for up to 24 h after disconnecting the chambers from the gas supply. We observed a significant reduction in the 53BP1 foci induced by laser-driven protons, conventional protons and X-rays in the hypoxic cells compared to normoxic cells at 30 min post-irradiation. Under hypoxic irradiations, the Laser-driven protons induced significant residual DNA DSB damage in hypoxic AG01522B cells compared to the conventional dose rate protons suggesting an important impact of these extremely high dose-rate exposures. We obtained an oxygen enhancement ratio (OER) of 2.1 ± 0.1 and 2.5 ± 0.1 respectively for the AG01522B and patient-derived GBM stem cells for X-ray irradiation using our hypoxia chambers.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10303 - Particles and field physics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Radiation Oncology
ISSN
1748-717X
e-ISSN
1748-717X
Volume of the periodical
17
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
77
UT code for WoS article
000782762500003
EID of the result in the Scopus database
2-s2.0-85128405304