Intraocular Pressure Response to Short-Term Extreme Normobaric Hypoxia Exposure

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73592723" target="_blank" >RIV/61989592:15310/19:73592723 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15510/19:73592723

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fendo.2018.00785/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fendo.2018.00785/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fendo.2018.00785" target="_blank" >10.3389/fendo.2018.00785</a>

Result language

angličtina

Original language name

Intraocular Pressure Response to Short-Term Extreme Normobaric Hypoxia Exposure

Original language description

Purpose: The purpose of the study was to determine the intraocular pressure response to normobaric hypoxia and the consequent recovery under additional well-controlled ambient conditions. Second, the study attempted to determine if the intraocular pressure changes were dependent on its baseline, initial heart rate, sex and arterial oxygen saturation. Methods: Thirty-eight visually healthy volunteers (23 women and 15 men) of an average age 25.2 +/- 3.8 years from 49 recruited participants met the inclusion criteria and performed the complete test. Initial intraocular pressure (baseline), heart rate, and arterial oxygen saturation were measured after 7 min of rest under normal ambient conditions at an altitude 250 m above sea level. Each subject then underwent a 10 min normobaric hypoxic exposure and a subsequent 7 min recovery under normoxic conditions. Within hypoxic period, subjects were challenged to breathe hypoxic gas mixture with fraction of inspired oxygen of 9.6% (similar to 6.200 m above sea level). Intraocular pressure and arterial oxygen saturation were re-measured at 4 and 10 min during the hypoxia and at 7 min after hypoxia termination. Results: Intraocular pressure increased in 1.2 mmHg +/- 1.9 mmHg and 0.9 mmHg +/- 2.3 mmHg at 4 and 10 min during the hypoxic period and returned approximately to the baseline at 7 min of recovery. The influence of sex was not statistically significant. The arterial oxygen saturation decreased in 14.9 +/- 4.2% at min 4 and 18.4 +/- 5.8% at min 10 during hypoxia and returned to the resting value at 7 min of recovery. The decrease was slightly higher in the case of women if compared with men. The hypoxia induced changes in intraocular pressure were significantly correlated with the arterial oxygen saturation changes, whereas the relationship with intraocular pressure baseline and initial heart rate were insignificant.Conclusion: There was a significant increase in intraocular pressure as a response to short-term normobaric hypoxia, which returned to the baseline in 7 min after hypoxia. The increase was dependent on the induced oxygen desaturation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

R - Projekt Ramcoveho programu EK

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Endocrinology

ISSN

1664-2392

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

JAN

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

"785-1"-"785-7"

UT code for WoS article

000455000400001

EID of the result in the Scopus database

2-s2.0-85064203144