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Comparison of chemical and electrochemical approaches to abacavir oxidative stability testing

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F23%3A00570736" target="_blank" >RIV/68378271:_____/23:00570736 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11310/23:10466231

  • Result on the web

    <a href="https://hdl.handle.net/11104/0342073" target="_blank" >https://hdl.handle.net/11104/0342073</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/s23052776" target="_blank" >10.3390/s23052776</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Comparison of chemical and electrochemical approaches to abacavir oxidative stability testing

  • Original language description

    A novel electrochemical approach using two different electrode materials, platinum and boron-doped diamond (BDD), was employed to study the oxidative stability of the drug abacavir. Abacavir samples were subjected to oxidation and subsequently analysed using chromatography with mass detection. The type and amount of degradation products were evaluated, and results were compared with traditional chemical oxidation using 3% hydrogen peroxide. The effect of pH on the rate of degradation and the formation of degradation products were also investigated. In general, both approaches led to the same two degradation products, identified using mass spectrometry, and characterised by 319.20 and m/z 247.19. Similar results were obtained on a large-surface platinum electrode at a potential of +1.15 V and a BDD disc electrode at +4.0 V.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Result continuities

  • Project

    <a href="/en/project/GA23-05688S" target="_blank" >GA23-05688S: Electrochemical sensors based on nanostructured and functionalized sp2 and sp3 carbon surfaces for (bio)analytical applications</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Sensors

  • ISSN

    1424-8220

  • e-ISSN

    1424-8220

  • Volume of the periodical

    23

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    12

  • Pages from-to

    2776

  • UT code for WoS article

    000947657900001

  • EID of the result in the Scopus database

    2-s2.0-85149774517