Comparison of chemical and electrochemical approaches to abacavir oxidative stability testing
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F23%3A00570736" target="_blank" >RIV/68378271:_____/23:00570736 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10466231
Result on the web
<a href="https://hdl.handle.net/11104/0342073" target="_blank" >https://hdl.handle.net/11104/0342073</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/s23052776" target="_blank" >10.3390/s23052776</a>
Alternative languages
Result language
angličtina
Original language name
Comparison of chemical and electrochemical approaches to abacavir oxidative stability testing
Original language description
A novel electrochemical approach using two different electrode materials, platinum and boron-doped diamond (BDD), was employed to study the oxidative stability of the drug abacavir. Abacavir samples were subjected to oxidation and subsequently analysed using chromatography with mass detection. The type and amount of degradation products were evaluated, and results were compared with traditional chemical oxidation using 3% hydrogen peroxide. The effect of pH on the rate of degradation and the formation of degradation products were also investigated. In general, both approaches led to the same two degradation products, identified using mass spectrometry, and characterised by 319.20 and m/z 247.19. Similar results were obtained on a large-surface platinum electrode at a potential of +1.15 V and a BDD disc electrode at +4.0 V.
Czech name
—
Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Result continuities
Project
<a href="/en/project/GA23-05688S" target="_blank" >GA23-05688S: Electrochemical sensors based on nanostructured and functionalized sp2 and sp3 carbon surfaces for (bio)analytical applications</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Sensors
ISSN
1424-8220
e-ISSN
1424-8220
Volume of the periodical
23
Issue of the periodical within the volume
5
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
2776
UT code for WoS article
000947657900001
EID of the result in the Scopus database
2-s2.0-85149774517