In vitro cytotoxicity evaluation of organotin(IV) complexes derived from bisphosphoramide ligand: DNA binding and molecular docking studies

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F23%3A00577711" target="_blank" >RIV/68378271:_____/23:00577711 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.molliq.2023.123442" target="_blank" >https://doi.org/10.1016/j.molliq.2023.123442</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.molliq.2023.123442" target="_blank" >10.1016/j.molliq.2023.123442</a>

Result language
angličtina
Original language name
In vitro cytotoxicity evaluation of organotin(IV) complexes derived from bisphosphoramide ligand: DNA binding and molecular docking studies
Original language description
Considering the valuable position of organotins and the biotic role of phosphorus compounds in biological processes, in this research work, we investigated and introduced a new class of anticancer candidates based on organotin(IV) complexes derived from bisphosphoramide ligands. Four selected complexes were prepared from the reaction of SnMe2Cl2 (C1), SnBu3Cl (C2), SnPh2Cl2 (C3), and SnPh3Cl (C4) metal salts with piperazine-1,4-diylbis(diphenylphosphine oxide) ligand (LP). The newly synthesized complexes were characterized using spectroscopic techniques. Single crystal of C1 structure was determined by X-ray crystallography. Binding potentials of compounds to DNA were also explored using electron absorption titration and competitive fluorescence quenching techniques, which indicated that complexes and CT-DNA strongly interacted.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Project
<a href="/en/project/LM2018110" target="_blank" >LM2018110: CzechNanoLab research infrastructure</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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