DNA nanostructures for rational regulation of cellular organelles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F25%3A00619458" target="_blank" >RIV/68378271:_____/25:00619458 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11320/25:10513049
Result on the web
<a href="https://hdl.handle.net/11104/0367813" target="_blank" >https://hdl.handle.net/11104/0367813</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/jacsau.5c00117" target="_blank" >10.1021/jacsau.5c00117</a>
Alternative languages
Result language
angličtina
Original language name
DNA nanostructures for rational regulation of cellular organelles
Original language description
DNA nanotechnology has revolutionized materials science and biomedicine by enabling precise manipulation of matter at the nanoscale. DNA nanostructures (DNs) in particular represent a promising frontier for targeted therapeutics. Engineered DNs offer unprecedented molecular programmability, biocompatibility, and structural versatility, making them ideal candidates for advanced drug delivery, organelle regulation, and cellular function modulation. This Perspective explores the emerging role of DNs in modulating cellular behavior through organelle-targeted interventions. We highlight current advances in nuclear, mitochondrial, and lysosomal targeting, showcasing applications ranging from gene delivery to cancer therapeutics. For instance, DNs have enabled precision mitochondrial disruption in cancer cells, lysosomal pH modulation to enhance gene silencing, and nuclear delivery of gene-editing templates. While DNs hold immense promise for advancing nanomedicine, outstanding challenges include optimizing biological interactions and addressing safety concerns. This Perspective highlights the current potential of DNs for rational control of targeted organelles, which could lead to novel therapeutic strategies and advancement of precision nanomedicines in the future.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/LUAUS24038" target="_blank" >LUAUS24038: Mechanical regulation of functionalized DNA nanostructures processing by hepatic cells</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JACS Au
ISSN
2691-3704
e-ISSN
2691-3704
Volume of the periodical
5
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
26
Pages from-to
1591-1616
UT code for WoS article
001455589700001
EID of the result in the Scopus database
2-s2.0-105003797720