Biodegradable Zn-0.8Mg-0.2Sr alloy as an internal fixation material exhibits controlled degradation with enhanced osteogenesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F25%3A00638536" target="_blank" >RIV/68378271:_____/25:00638536 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/25:43933113
Result on the web
<a href="https://hdl.handle.net/11104/0369914" target="_blank" >https://hdl.handle.net/11104/0369914</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d5ra02009c" target="_blank" >10.1039/d5ra02009c</a>
Alternative languages
Result language
angličtina
Original language name
Biodegradable Zn-0.8Mg-0.2Sr alloy as an internal fixation material exhibits controlled degradation with enhanced osteogenesis
Original language description
Zinc (Zn) and its alloys are promising candidates for biodegradable metals in medical applications. However, their clinical use in internal fixation is hindered by low mechanical strength, uncontrolled corrosion, and insufficient bioactivity. To address these issues, we developed an extruded Zn-0.8Mg-0.2Sr ternary alloy and systematically evaluated its biological performance. In vitro corrosion tests indicated that Zn-0.8Mg-0.2Sr exhibited superior corrosion resistance, attributed to a dense passivation layer that provided effective protection, controlled degradation kinetics, and milder Zn2+ release. The cytotoxicity of Zn-0.8Mg-0.2Sr toward pre-osteoblasts was concentration-dependent. Within the non-cytotoxic concentration range (Zn2+ ≤8.98 μg mL−1), Zn-0.8Mg-0.2Sr promoted osteogenic differentiation more effectively than pure Zn. Further in vivo studies confirmed favorable biocompatibility and more uniform degradation of Zn-0.8Mg-0.2Sr, with reduced pitting corrosion and structural collapse. Notably, Zn-0.8Mg-0.2Sr exhibited superior performance in promoting bone regeneration and anti-inflammatory immunomodulation compared to pure Zn. These findings highlight Zn-0.8Mg-0.2Sr as a promising alternative to conventional internal fixation materials, offering favorable biocompatibility, controlled biodegradability, and enhanced osteogenesis.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)
Result continuities
Project
<a href="/en/project/GA23-05592S" target="_blank" >GA23-05592S: Influence of surface modifications on the functionality of zinc-based absorbable materials for applications in bone reconstructions</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RSC Advances
ISSN
2046-2069
e-ISSN
2046-2069
Volume of the periodical
15
Issue of the periodical within the volume
37
Country of publishing house
GB - UNITED KINGDOM
Number of pages
18
Pages from-to
30071-30088
UT code for WoS article
001554775300001
EID of the result in the Scopus database
2-s2.0-105013781736