Copperfluidics: Controlled Cu0-Mediated SI-ATRP under Flow for High-Precision Polymer Brush Synthesis Monitored by QCM-D
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F25%3A00639780" target="_blank" >RIV/68378271:_____/25:00639780 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1109/IWASI66786.2025.11121930" target="_blank" >http://dx.doi.org/10.1109/IWASI66786.2025.11121930</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1109/IWASI66786.2025.11121930" target="_blank" >10.1109/IWASI66786.2025.11121930</a>
Alternative languages
Result language
angličtina
Original language name
Copperfluidics: Controlled Cu0-Mediated SI-ATRP under Flow for High-Precision Polymer Brush Synthesis Monitored by QCM-D
Original language description
The development of robust antifouling surfaces is critical for reliable label-free biosensing in complex biological samples. One effective approach uses zwitterionic polymer brushes synthesized via surface-initiated atom transfer radical polymerization (SI-ATRP): a method where the CuI/CuII ratio can control the polymer brush characteristics, albeit where deoxygenated conditions complicate synthesis. Here, we use a copper-based microreactor to simultaneously deoxygenate the solution and generate CuI. Integration into a microfluidic system allowed controlled polymerization of an antifouling zwitterionic homopolymer brush, poly(carboxybetaine methacrylamide) (pCBMAA). The polymerization process is monitored in real time by the quartz crystal microbalance with dissipation monitoring (QCM-D) method. The resulting surfaces were characterized by FT-IR and spectroscopic ellipsometry, and the results were compared with those obtained by QCM-D method.The pCBMAA-coated surfaces exhibited excellent antifouling performance in 50% human blood plasma, confirming their suitability for biosensing in complex matrices. Furthermore, successful antibody functionalization enabled the detection of E. coli O157:H7, demonstrating the versatility of these brushes for specific biomolecular interactions.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
2025 IEEE International Workshop on Advances in Sensors and Interfaces (IWASI)
ISBN
979-8-3315-6579-4
ISSN
2836-8681
e-ISSN
—
Number of pages
5
Pages from-to
11121930
Publisher name
IEEE
Place of publication
Piscataway
Event location
Manfredonia
Event date
Jul 3, 2025
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
001568944200029