Is GGAG:Ce@SiO2-RB composite a prospective material for X-ray induced photodynamic therapy?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F25%3A00640829" target="_blank" >RIV/68378271:_____/25:00640829 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21340/25:00387981

Result on the web

<a href="https://doi.org/10.1016/j.radphyschem.2025.112942" target="_blank" >https://doi.org/10.1016/j.radphyschem.2025.112942</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.radphyschem.2025.112942" target="_blank" >10.1016/j.radphyschem.2025.112942</a>

Result language

angličtina

Original language name

Is GGAG:Ce@SiO2-RB composite a prospective material for X-ray induced photodynamic therapy?

Original language description

Nanocomposite material (GGAG:Ce3+@SiO2-RB) for potential use in X-ray induced photodynamic therapy (X-PDT) was developed, thoroughly characterized, and evaluated. It consists of a scintillating Gd3(Ga1-xAlx)5O12:Ce3+ core encapsulated in silica layer and functionalized with the photosensitizer Rose Bengal (RB). Radioluminescence measurements confirmed the energy transfer from the scintillating core to Rose Bengal. Dark toxicity and radiosensitisation effects were evaluated using Saccharomyces cerevisiae as a model organism. The nanocomposite showed minimal dark toxicity at concentrations of up to 10 mg/mL. However, X-ray irradiation experiments did not demonstrate significant singlet oxygen production compared to the controls. Although the nanocomposite design shows potential, further optimization is needed to achieve an effective X-PDT performance.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Radiation Physics and Chemistry

ISSN

0969-806X

e-ISSN

1879-0895

Volume of the periodical

236

Issue of the periodical within the volume

Nov

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

112942

UT code for WoS article

001502108300002

EID of the result in the Scopus database

2-s2.0-105005871941