Blood Coagulation Dynamics: Mathematical Modeling and Stability Results
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F11%3A00181488" target="_blank" >RIV/68407700:21220/11:00181488 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3934/mbe.2011.8.425" target="_blank" >http://dx.doi.org/10.3934/mbe.2011.8.425</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3934/mbe.2011.8.425" target="_blank" >10.3934/mbe.2011.8.425</a>
Alternative languages
Result language
angličtina
Original language name
Blood Coagulation Dynamics: Mathematical Modeling and Stability Results
Original language description
The hemostatic system is a complex biosystem that under normal physiologic conditions maintains the fluidity of blood. Coagulation is initiated in response to endothelial surface vascular injury or certain biochemical stimuli, by the exposure of plasma to Tissue Factor (TF), that activates platelets and the coagulation cascade,inducing clot formation, growth and lysis. In this paper a mathematical model of coagulation and fibrinolysis in flowing blood that integrates biochemical, physiologic and rheological factors, is revisited. Three-dimensional numerical simulations are performed in an idealized stenosed blood vessel where clot formation and growth are initialized through appropriate boundary conditions on the vessel wall. Stability results are obtained for a simplified version of the clot model in quiescent plasma, involving some of the most relevant enzymatic reactions that follow Michaelis-Menten kinetics, and having a continuum of equilibria.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BK - Liquid mechanics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mathematical Biosciences and Engineering
ISSN
1547-1063
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
19
Pages from-to
425-443
UT code for WoS article
000290095400013
EID of the result in the Scopus database
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