PDMS substrate stiffness affects the morphology and growth profiles of cancerous prostate and melanoma cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F15%3A00221130" target="_blank" >RIV/68407700:21220/15:00221130 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S175161611400304X#" target="_blank" >http://www.sciencedirect.com/science/article/pii/S175161611400304X#</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jmbbm.2014.09.020" target="_blank" >10.1016/j.jmbbm.2014.09.020</a>
Alternative languages
Result language
angličtina
Original language name
PDMS substrate stiffness affects the morphology and growth profiles of cancerous prostate and melanoma cells
Original language description
A deep understanding of the interaction between cancerous cells and surfaces is particularly important for the design of lab-on-chip devices involving the use of poly-dimethylsiloxane (PDMS). In our studies, the effect of PDMS substrate stiffness on mechanical properties of cancerous cells was investigated in conditions where the PDMS substrate is not covered with any of extracellular matrix proteins. Two human prostate cancer (Du145 and PC-3) and two melanoma (WM115 and WM266-4) cell lines were cultured on two groups of PDMS substrates that were characterized by istinct stiffness, i.e. 0.75MPa and 2.92 MPa. The results showed the strong effect on cellular behavior and orphology. The detailed analysis of chemical and physical properties of substrates revealed that cellular behavior occurs only due to substrate elasticity.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/TA01010185" target="_blank" >TA01010185: New materials and coatings for joint replacement bionical design</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of the Mechanical Behavior of Biomedical Materials
ISSN
1751-6161
e-ISSN
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Volume of the periodical
41
Issue of the periodical within the volume
January
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
13-22
UT code for WoS article
000346217400002
EID of the result in the Scopus database
2-s2.0-84908301569