Elastic Properties of Human Osteon and Osteonal Lamella Computed by a Bidirectional Micromechanical Model and Validated by Nanoindentation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F15%3A00229378" target="_blank" >RIV/68407700:21220/15:00229378 - isvavai.cz</a>

Result on the web

<a href="http://biomechanical.asmedigitalcollection.asme.org/article.aspx?articleid=2279321" target="_blank" >http://biomechanical.asmedigitalcollection.asme.org/article.aspx?articleid=2279321</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1115/1.4030407" target="_blank" >10.1115/1.4030407</a>

Result language

angličtina

Original language name

Elastic Properties of Human Osteon and Osteonal Lamella Computed by a Bidirectional Micromechanical Model and Validated by Nanoindentation

Original language description

Knowledge of the anisotropic elastic properties of osteon and osteonal lamellae provides a better understanding of various pathophysiological conditions, such as aging, osteoporosis, osteoarthritis and other degenerative diseases. For this reason, it is important to investigate and understand the elasticity of cortical bone. We created a bidirectional micromechanical model based on inverse homogenization for predicting the elastic properties of osteon and osteonal lamellae of cortical bone. The shape, the dimensions and the curvature of osteon and osteonal lamellae are described by appropriately chosen curvilinear coordinate systems, so the model operates close to the real morphology of these bone components. The model was used to calculate nine orthotropic elastic constants of osteonal lamellae. The input values have the elastic properties of a single osteon. We also expressed the dependence of the elastic properties of the lamellae on the angle of orientation. To validate the model, we performed nanoindentation tests on several osteonal lamellae. We compared the experimental results with the calculated results, and there was good agreement between them. The inverted model was used to calculate the elastic properties of a single osteon, where the input values are the elastic constants of osteonal lamellae. These calculations reveal that the model can be used in both directions of homogenization, i.e. direct homogenization and also inverse homogenization. The model described here can provide either the unknown elastic properties of a single lamella from the known elastic properties at the level of a single osteon, or the unknown elastic properties of a single osteon from the known elastic properties at the level of a single lamella.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EI - Biotechnology and bionics

OECD FORD branch

—

Project

<a href="/en/project/TA01010185" target="_blank" >TA01010185: New materials and coatings for joint replacement bionical design</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Biomechanical Engineering

ISSN

0148-0731

e-ISSN

—

Volume of the periodical

137

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

—

UT code for WoS article

000357336300002

EID of the result in the Scopus database

2-s2.0-84931282141