Stability of Phospholipid Vesicles in Joint - Mathematical Model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F15%3A00241367" target="_blank" >RIV/68407700:21220/15:00241367 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Stability of Phospholipid Vesicles in Joint - Mathematical Model
Original language description
Articular cartilage has a frictional properties that remains unmatched by industrial joints. The mechanisms by which the synovial joint achieves these properties involve combination of biomechanical and biomolecular factors. The principles of cartilage lubrication has been studied for many decades, but the exact lubrication mechanism remains unclear. In the last decades, it has been proposed that surface-active phospholipids (SAPL) serve as the boundary lubricant. Lamellar structures of phospholipids reduce the coefficient of friction thus lessening wear of the articular surfaces, even under high loads. The aim of this study is to test the hypothesis whether or not phospholipid vesicles in synovial fluid may contribute to creation of lamellar layer at cartilage under physiological load.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů