Effect of cross-linking agent concentration on mechanical properties of Collagen-CaP nanostructured composite
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F17%3A00315933" target="_blank" >RIV/68407700:21220/17:00315933 - isvavai.cz</a>
Result on the web
<a href="http://stc.fs.cvut.cz/pdf17/6581.pdf?_=1491491475" target="_blank" >http://stc.fs.cvut.cz/pdf17/6581.pdf?_=1491491475</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Effect of cross-linking agent concentration on mechanical properties of Collagen-CaP nanostructured composite
Original language description
An infection is responsible for many complications accompanying orthopedic surgery. Osteomyelitis may lead to total implant failure due to loosening of the prosthesis. Such a situation frequently results in necessity of re-implantation. To avoid potential post-surgery complications, various solutions are available. Our study is devoted to optimization of preparation methods for collagen-CaP nanostructured composite aimed to function as a drug carrier. The collagen-CaP composite will be used as implant surface coating. In this paper, the effect of crosslinking conditions on mechanical properties and structural stability of collagen-CaP is studied. Three different concentrations of an ethanol solution of N-(3-dimethylaminopropyl)-N0-ethylcarbodiimide hydrochloride/N-hydroxy-succinimide were used to cross-link electrospinned collagen-CaP layer for 24 hours. The mechanical properties were evaluated by means of uniaxial tensile tests and structural stability was assessed via SEM and degradation test. The results suggest that crosslinking improves all studied properties.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
20505 - Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics; filled composites)
Result continuities
Project
<a href="/en/project/TA04010330" target="_blank" >TA04010330: Development of resorbable collagen-calcium phosphate nanolayer with controlled elution of antibiotics for implants survival rate enhancement</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů