Experimental evaluation of liposomes biomechanics

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F21%3A00353070" target="_blank" >RIV/68407700:21220/21:00353070 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21460/21:00353070

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Experimental evaluation of liposomes biomechanics

Original language description

The aim of our study is to create liposomes using a microfluidic device and use them as a mechanical reference for force probe testing methods such as AFM or nanoindentation. Two types of liposomes were produced using a custom microfluidic device. The first type is simple unilamellar phospholipid vesicles while the second type contains HA (hyaluronic acid) mimicking the role of cytoplasm. Mathematical model was developed to determine the mechanical properties of individual constituents from AFM and nanoindentation force curves, i.e. the area compression module of lipid bilayer and the elasticity modulus of cytoplasm.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

20505 - Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics; filled composites)

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů