Mechanical Response of Explanted Collagen-nanofiber Composites Intended for Pulmonary Artery Banding

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F22%3A00358168" target="_blank" >RIV/68407700:21220/22:00358168 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Mechanical Response of Explanted Collagen-nanofiber Composites Intended for Pulmonary Artery Banding

Original language description

Pulmonary artery banding (PAB) is an intervention used in neonates suffering from certain congenital heart diseases to reduce pulmonary over-circulation. Our project deals with the research and development of a new banding material based on collagen-polycaprolactone (COLL-PCL) and collagen-poly[L-lactide/caprolactone] (COLL-PLCL) composites. The composites are biodegradable and give the advantage of PAB as a one-step procedure. However, the rate of degradation of the composites in a real body environment is unknown but can be determined by means of biomechanical analysis. COLL-PCL and COLL-PLCL materials were prepared by electrospinning, followed by the impregnation of the layers with collagen (type I) dispersion and implanted into the abdominal walls of adult Wistar rats. The composites were explanted after 4 weeks and their mechanical properties were evaluated by means of the uniaxial tensile test. Both COLL-PCL and COLL-PLCL were found to maintain their integrity up to explantation, and the results of the tensile experiments confirmed sufficient ultimate stress (0.51 ± 0.13 MPa).

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Project

<a href="/en/project/NU20-02-00368" target="_blank" >NU20-02-00368: Biomechanically defined absorbable materials for cardiovascular surgery</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

EAN 2021 59th conference on experimental stress analysis

ISBN

978-80-01-06885-4

ISSN

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e-ISSN

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Number of pages

4

Pages from-to

236-239

Publisher name

katedra mechaniky

Place of publication

Praha

Event location

Litomyšl

Event date

Sep 29, 2021

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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