Deregulated Genes and Pathways in Human Embryonic Lung Fibroblasts (HEL 12469) treated with Complex Mixtures of the Air Pollutants

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F11%3A00204063" target="_blank" >RIV/68407700:21230/11:00204063 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/em.20693/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/em.20693/pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Deregulated Genes and Pathways in Human Embryonic Lung Fibroblasts (HEL 12469) treated with Complex Mixtures of the Air Pollutants
Original language description
Recently, we have demonstrated the genotoxic activities of complex mixtures of organic extracts from urban air particles collected in various localities of the Czech Republic that differ in the extent and sources of air pollution [Topinka et al., Toxicology Lett. 202 (2011) 186- 192]. In this study, human embryonic lung fibroblasts (HEL12469) were employed to assess changes in gene expression profiles induced by complex mixtures of organic air pollutants adsorbed onto respirable air particles (PM2.5) collected by high volume samplers in 4 localities of the Czech Republic (Ostrava-Bartovice, Ostrava-Poruba, Karvina and Trebon). For this purpose, changes in the genome-wide expression profiles induced by extractable organic matter (EOM) from the PM2.5 particles were analyzed at subtoxic EOM concentrations of 10, 30, and 60 ?g EOM/ml. Dose dependent increases of a number of deregulated genes were observed for all EOMs. Multiple transcripts/genes are significantly correlating with B[a]P con
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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