Analysis of Gene Expression Changes in A549 Cells Induced by Organic Compounds from Respirable Air Particles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F14%3A00221690" target="_blank" >RIV/68407700:21230/14:00221690 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/14:00435218 RIV/00027162:_____/14:#0001185
Result on the web
<a href="http://dx.doi.org/10.1016/j.mrfmmm.2014.10.002" target="_blank" >http://dx.doi.org/10.1016/j.mrfmmm.2014.10.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mrfmmm.2014.10.002" target="_blank" >10.1016/j.mrfmmm.2014.10.002</a>
Alternative languages
Result language
angličtina
Original language name
Analysis of Gene Expression Changes in A549 Cells Induced by Organic Compounds from Respirable Air Particles
Original language description
A number of toxic effects of respirable ambient air particles (genotoxic effects, inflammation, oxidative damage) have been attributed to organic compounds bound onto the particle surface. In this study, we analyzed global gene expression changes causedby the extractable organic matters (EOMs) from respirable airborne particles <2.5 ?m (PM2.5), collected at 3 localities from heavily polluted areas of the Czech Republic and a control locality with low pollution levels, in human lung epithelial A549 cells. Although the sampled localities differed in both extent and sources of air pollution, EOMs did not induce substantially different gene expression profiles. The number of transcripts deregulated in A549 cells treated with the lowest EOM concentration (10 ?g/ml) ranged from 65 to 85 in 4 sampling localities compared to the number of transcripts deregulated after 30 ?g/ml and 60 ?g/ml of EOMs, which ranged from 90 to 109, and from 149 to 452, respectively. We found numerous commonly dere
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
JC - Computer hardware and software
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
ISSN
0027-5107
e-ISSN
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Volume of the periodical
770
Issue of the periodical within the volume
December
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
12
Pages from-to
94-105
UT code for WoS article
000345647400012
EID of the result in the Scopus database
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