Global Gene Expression Changes Induced by Organic Extracts of Air Pollutants in Human Lung Cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F13%3A00204084" target="_blank" >RIV/68407700:21230/13:00204084 - isvavai.cz</a>
Result on the web
<a href="http://www.toxicology.org/AI/PUB/Tox/2013Tox.pdf" target="_blank" >http://www.toxicology.org/AI/PUB/Tox/2013Tox.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Global Gene Expression Changes Induced by Organic Extracts of Air Pollutants in Human Lung Cells
Original language description
Many adverse effects of the ambient air pollution have been linked to polycyclic aromatic hydrocarbons (PAHs) occurring in the complex mixture adsorbed onto airborne particles. Besides their genotoxic effect, some of them are known to act via aryl hydrocarbon receptor (AhR)-mediated nongenotoxic and tumor promoting mechanism. This study employed human lung adenocarcinoma cells (A549) to investigace the effect of complex mixture of the air pollutants on the global gene expression changes. We determined whole-genome gene expression profiles (Illumina platform) of cells treated with organic extracts (EOMs) from particulate matter (<2.5 ?m) collected in four localities in the Czech Republic differing in the level of the air pollution. Simultaneously, detailed chemical analysis of EOMs from each lokality was performed. Despite various sources, EOMs exhibited equal qualitative composition although the absolute level of PAHs and other pollutants in the most polluted locality was much higher c
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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