Comparative Validation of Computer Programs for Haplotype Frequency Estimation from Donor Registry Data

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F13%3A00206568" target="_blank" >RIV/68407700:21230/13:00206568 - isvavai.cz</a>

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1111/tan.12160/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/tan.12160/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/tan.12160" target="_blank" >10.1111/tan.12160</a>

Result language

angličtina

Original language name

Comparative Validation of Computer Programs for Haplotype Frequency Estimation from Donor Registry Data

Original language description

Estimation of human leukocyte antigen (HLA) haplotype frequencies from unrelated stem cell donor registries presents a challenge because of large sample sizes and heterogeneity of HLA typing data. For the 14th International HLA and Immunogenetics Workshop, five bioinformatics groups initiated the `Registry Diversity Component? aiming to cross-validate and improve current haplotype estimation tools. Five datasets were derived from different donor registries and then used as input for five different computer programs for haplotype frequency estimation. Because of issues related to heterogeneity and complexity of HLA typing data identified in the initial phase, the same five implementations, and two new ones, were used on simulated datasets in a controlled experiment where the correct results were known a priori. These datasets contained various fractions of missing HLA-DR modeled after European haplotype frequencies. We measured the contribution of sampling fluctuation and estimation err

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

JC - Computer hardware and software

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Tissue Antigens - Immune Response Genetics

ISSN

0001-2815

e-ISSN

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Volume of the periodical

82

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

93-105

UT code for WoS article

000321697900002

EID of the result in the Scopus database

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