Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F21%3A00350942" target="_blank" >RIV/68407700:21230/21:00350942 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/S1474-4422(21)00176-9" target="_blank" >https://doi.org/10.1016/S1474-4422(21)00176-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/S1474-4422(21)00176-9" target="_blank" >10.1016/S1474-4422(21)00176-9</a>
Alternative languages
Result language
angličtina
Original language name
Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder
Original language description
Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly regarded as being in the early stages of a progressive neurodegenerative disease involving α-synuclein pathology, such as Parkinson’s disease, dementia with Lewy bodies, or multiple system atrophy. Abnormal α-synuclein deposition occurs early in the neurodegenerative process across the central and peripheral nervous systems and might precede the appearance of motor symptoms and cognitive decline by several decades. These findings provide the rationale to develop reliable biomarkers that can better predict conversion to clinically manifest α-synucleinopathies. In addition, biomarkers of disease progression will be essential to monitor treatment response once disease-modifying therapies become available, and biomarkers of disease subtype will be essential to enable prediction of which subtype of α-synucleinopathy patients with isolated RBD might develop.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
<a href="/en/project/NU20-08-00445" target="_blank" >NU20-08-00445: Smart Speech Biomarkers for Parkinson’s Disease and Other Synucleinopathies</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Lancet Neurology
ISSN
1474-4422
e-ISSN
1474-4465
Volume of the periodical
20
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
671-684
UT code for WoS article
000677684700019
EID of the result in the Scopus database
2-s2.0-85110583357