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Speech and gait abnormalities in motor subtypes of de-novo Parkinson's disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F23%3A00367040" target="_blank" >RIV/68407700:21230/23:00367040 - isvavai.cz</a>

  • Alternative codes found

    RIV/68407700:21460/23:00367040 RIV/00216208:11110/23:10458845 RIV/00216208:11310/23:10458845 RIV/00064165:_____/23:10458845

  • Result on the web

    <a href="https://doi.org/10.1111/cns.14158" target="_blank" >https://doi.org/10.1111/cns.14158</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/cns.14158" target="_blank" >10.1111/cns.14158</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Speech and gait abnormalities in motor subtypes of de-novo Parkinson's disease

  • Original language description

    AimTo investigate the presence and relationship of temporal speech and gait parameters in patients with postural instability/gait disorder (PIGD) and tremor-dominant (TD) motor subtypes of Parkinson's disease (PD). MethodsSpeech samples and instrumented walkway system assessments were acquired from a total of 60 de-novo PD patients (40 in TD and 20 in PIGD subtype) and 40 matched healthy controls. Objective acoustic vocal assessment of seven distinct speech timing dimensions was related to instrumental gait measures including velocity, cadence, and stride length. ResultsCompared to controls, PIGD subtype showed greater consonant timing abnormalities by prolonged voice onset time (VOT) while also shorter stride length during both normal walking and dual task, while decreased velocity and cadence only during dual task. Speaking rate was faster in PIGD than TD subtype. In PIGD subtype, prolonged VOT correlated with slower gait velocity (r = -0.56, p = 0.01) and shorter stride length (r = -0.59, p = 0.008) during normal walking, whereas relationships were also found between decreased cadence in dual task and irregular alternating motion rates (r = -0.48, p = 0.04) and prolonged pauses (r = -0.50, p = 0.03). No correlation between speech and gait was detected in TD subtype. ConclusionOur findings suggest that speech and gait rhythm disorder share similar underlying pathomechanisms specific for PIGD subtype.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30210 - Clinical neurology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    CNS Neuroscience and Therapeutics

  • ISSN

    1755-5930

  • e-ISSN

    1755-5949

  • Volume of the periodical

    29

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    2101-2110

  • UT code for WoS article

    000953661700001

  • EID of the result in the Scopus database

    2-s2.0-85150882634