Impaired dual-task gait in Parkinson’s disease is associated with brain morphology changes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F24%3A00372869" target="_blank" >RIV/68407700:21460/24:00372869 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/24:10479962 RIV/00064165:_____/24:10479962

Result on the web

<a href="https://doi.org/10.1007/s00702-024-02758-2" target="_blank" >https://doi.org/10.1007/s00702-024-02758-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-024-02758-2" target="_blank" >10.1007/s00702-024-02758-2</a>

Result language

angličtina

Original language name

Impaired dual-task gait in Parkinson’s disease is associated with brain morphology changes

Original language description

In Parkinson’s disease (PD), impaired gait and cognition affect daily activities, particularly in the more advanced stages of the disease. This study investigated the relationship between gait parameters, cognitive performance, and brain morphology in patients with early untreated PD. 64 drug-naive PD patients and 47 healthy controls (HC) participated in the study. Single- and dual-task gait (counting task) were examined using an expanded Timed Up & Go Test measured on a GaitRite walkway. Measurements included gait speed, stride length, and cadence. A brain morphometry analysis was performed on T1-weighted magnetic resonance (MR) images. In PD patients compared to HC, gait analysis revealed reduced speed (p < 0.001) and stride length (p < 0.001) in single-task gait, as well as greater dual-task cost (DTC) for speed (p = 0.007), stride length (p = 0.014) and cadence (p = 0.029). Based on the DTC measures in HC, PD patients were further divided into two subgroups with normal DTC (PD-nDTC) and abnormally increased DTC (PD-iDTC). For PD-nDTC, voxel-based morphometric correlation analysis revealed a positive correlation between a cluster in the left primary motor cortex and stride-length DTC (r = 0.57, p = 0.027). For PD-iDTC, a negative correlation was found between a cluster in the right lingual gyrus and the DTC for gait cadence (r=-0.35, pFWE = 0.018). No significant correlations were found in HC. The associations found between brain morphometry and gait performance with a concurrent cognitive task may represent the substrate for gait and cognitive impairment occurring since the early stages of PD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

1435-1463

Volume of the periodical

131

Issue of the periodical within the volume

12

Country of publishing house

AT - AUSTRIA

Number of pages

7

Pages from-to

1389-1395

UT code for WoS article

001173152000002

EID of the result in the Scopus database

2-s2.0-85186450214