Degeneration of the cholinergic system in individuals with subjective cognitive decline: A systematic review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F24%3A00374612" target="_blank" >RIV/68407700:21230/24:00374612 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21730/24:00374612

Result on the web

<a href="https://doi.org/10.1016/j.neubiorev.2024.105534" target="_blank" >https://doi.org/10.1016/j.neubiorev.2024.105534</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neubiorev.2024.105534" target="_blank" >10.1016/j.neubiorev.2024.105534</a>

Result language

angličtina

Original language name

Degeneration of the cholinergic system in individuals with subjective cognitive decline: A systematic review

Original language description

Background: Subjective cognitive decline (SCD) is a risk factor for future cognitive impairment and dementia. It is uncertain whether the neurodegeneration of the cholinergic system is already present in SCD individuals. We aimed to review the current evidence about the association between SCD and biomarkers of degeneration in the cholinergic system. Method: Original articles were extracted from three databases: Pubmed, Web of Sciences, and Scopus, in January 2023. Two researchers screened the studies independently. Results: A total of 11 research articles were selected. SCD was mostly based on amnestic cognitive complaints. Cholinergic system biomarkers included neuroimaging markers of basal forebrain volume, functional connectivity, transcranial magnetic stimulation, or biofluid. The evidence showed associations between basal forebrain atrophy, poorer connectivity of the cholinergic system, and SCD Conclusions: Degenerative changes in the cholinergic system can be present in SCD. Subjective complaints may help when identifying individuals with brain changes that are associated with cognitive impairment. These findings may have important implications in targeting individuals that may benefit from cholinergic-target treatments at very early stages of neurodegenerative diseases.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroscience and Biobehavioral Reviews

ISSN

0149-7634

e-ISSN

1873-7528

Volume of the periodical

157

Issue of the periodical within the volume

February

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

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UT code for WoS article

001162522600001

EID of the result in the Scopus database

2-s2.0-85182630418