Enhancing the Mapping of Irritative Network in Focal Cortical Dysplasia: Sorting Multifocal Interictal Epileptiform Discharges

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F24%3A00378375" target="_blank" >RIV/68407700:21230/24:00378375 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1109/EHB64556.2024.10805668" target="_blank" >http://dx.doi.org/10.1109/EHB64556.2024.10805668</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/EHB64556.2024.10805668" target="_blank" >10.1109/EHB64556.2024.10805668</a>

Result language

angličtina

Original language name

Enhancing the Mapping of Irritative Network in Focal Cortical Dysplasia: Sorting Multifocal Interictal Epileptiform Discharges

Original language description

Abstract—Interictal epileptiform discharges (IED) are an electrophysiological hallmark of epilepsy, and their occurrence characterizes brain tissue that is connected to the epileptic network of focal epilepsy - irritative zone (IZ). IZ is composed of partially overlapped sub-regions generating IED independently. Various ways of spreading IEDs complicate localization of IED sources resulting in sub-regional fragmentation or insufficient decomposition using signal analysis of stereo-EEG monitoring for surgical treatment of epilepsy. We localized the sources of IED for each sub-region of highly fragmented IZ resulting from the previously published algorithm. To identify and merge sub-regions having the same IED source, we designed and optimized an iterative algorithm using additional spatial coordinates of all intracranial EEG recording contacts. Forty-four patients with focal cortical dysplasia (FCD), who underwent epilepsy surgery, were analyzed to find criteria for maximal reduction in the number of sub-regions while maintaining clinically relevant IZ decomposition. The optimal Euclidian distance between any IED sources that result in the merging of sub-regions was found at R = 10.6 mm. The approach used significantly reduced the number of the subregions to six at the median (p=0.004, U-test) with a lower mutual overlap of 10.7 % (p<0.002, U-test). The presented method reduces the sub-regional fragmentation of IZ and maintains a detailed description of the epileptic network. It facilitates the advance of detailed analysis of the interaction between epileptic focus, IED generators, and the effect of their removal by surgery in clinical practice.

Czech name

—

Czech description

—

Type

D - Article in proceedings

CEP classification

—

OECD FORD branch

20601 - Medical engineering

Project

<a href="/en/project/NU21J-08-00081" target="_blank" >NU21J-08-00081: Hippocampal involvement in neocortical epilepsy networks: Implications for surgical planning</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

2024 E-Health and Bioengineering Conference (EHB)

ISBN

979-8-3315-3214-7

ISSN

2575-5145

e-ISSN

2575-5145

Number of pages

4

Pages from-to

—

Publisher name

IEEE Industrial Electronic Society

Place of publication

Vienna

Event location

Iasi

Event date

Nov 14, 2024

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

001413708800040