Structural and microstructural predictors of cognitive decline in deep brain stimulation of subthalamic nucleus in Parkinson's disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F24%3A00382479" target="_blank" >RIV/68407700:21230/24:00382479 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/24:10480743 RIV/00216208:11120/24:43927027 RIV/00023884:_____/24:00009865 RIV/00064165:_____/24:10480743

Result on the web

<a href="https://doi.org/10.1016/j.nicl.2024.103617" target="_blank" >https://doi.org/10.1016/j.nicl.2024.103617</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nicl.2024.103617" target="_blank" >10.1016/j.nicl.2024.103617</a>

Result language

angličtina

Original language name

Structural and microstructural predictors of cognitive decline in deep brain stimulation of subthalamic nucleus in Parkinson's disease

Original language description

Background and objectives: The intricate relationship between deep brain stimulation (DBS) in Parkinson ' s disease (PD) and cognitive impairment has lately garnered substantial attention. The presented study evaluated pre-DBS structural and microstructural cerebral patterns as possible predictors of future cognitive decline in PD DBS patients. Methods: Pre-DBS MRI data in 72 PD patients were combined with neuropsychological examinations and followup for an average of 2.3 years after DBS implantation procedure using a screening cognitive test validated for diagnosis of mild cognitive impairment in PD in a Czech population - Dementia Rating Scale 2. Results: PD patients who would exhibit post-DBS cognitive decline were found to have, already at the pre-DBS stage, significantly lower cortical thickness and lower microstructural complexity than cognitively stable PD patients. Differences in the regions directly related to cognition as bilateral parietal, insular and cingulate cortices, but also occipital and sensorimotor cortex were detected. Furthermore, hippocampi, putamina, cerebellum and upper brainstem were implicated as well, all despite the absence of pre-DBS differences in cognitive performance and in the position of DBS leads or stimulation parameters between the two groups. Conclusions: Our findings indicate that the cognitive decline in the presented PD cohort was not attributable primarily to DBS of the subthalamic nucleus but was associated with a clinically silent structural and microstructural predisposition to future cognitive deterioration present already before the DBS system implantation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroimage: Clinical

ISSN

2213-1582

e-ISSN

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Volume of the periodical

42

Issue of the periodical within the volume

103617

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

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UT code for WoS article

001242427300001

EID of the result in the Scopus database

2-s2.0-85192772219