Mixed anxiety-depressive disorder in Parkinson 's disease associated with worse resting state functional response to deep brain stimulation of subthalamic nucleus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F24%3A00009905" target="_blank" >RIV/00023884:_____/24:00009905 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/24:10480738 RIV/00216208:11120/24:43927030 RIV/00064165:_____/24:10480738

Result on the web

<a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11109721/" target="_blank" >https://pmc.ncbi.nlm.nih.gov/articles/PMC11109721/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.heliyon.2024.e30698" target="_blank" >10.1016/j.heliyon.2024.e30698</a>

Result language

angličtina

Original language name

Mixed anxiety-depressive disorder in Parkinson 's disease associated with worse resting state functional response to deep brain stimulation of subthalamic nucleus

Original language description

Background: Parkinson's disease (PD), even though generally perceived as a dominantly motor disorder, is associated with a wide range of non-motor symptoms, including mixed anxietydepressive disorder (MADD). Objectives: The aim of the presented study was to determine whether deep brain stimulation (DBS) of the subthalamic nucleus (STN) brings the functional characteristics of non-motor networks closer to the condition detected in healthy population and whether pre-DBS presence of MADD in PD patients was associated with different reaction to this therapeutic modality. Methods: Resting-state fMRI signature elicited by STN DBS activation and deactivation in 81 PD patients was compared against healthy controls, with the focus on measures of efficiency of information processing and localised subnetwork differences. Results: While all the MRI metrics showed statistically significant differences between PD patients in DBS OFF condition and healthy controls, none were detected in such a comparison against DBS ON condition. Furthermore, in the post-DBS evaluation, PD patients with MADD in the pre-DBS stage showed no differences in depression scales compared to pre-DBS psychiatrically intact PD patients, but still exhibited lower DBS-related connectivity in a subnetwork encompassing anterior and posterior cingulate, dorsolateral prefrontal and medial temporal cortices.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Heliyon

ISSN

2405-8440

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

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UT code for WoS article

001243952600001

EID of the result in the Scopus database

2-s2.0-85192999720