Long-term dopaminergic therapy improves spoken language in de-novo Parkinson's disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F25%3A00383339" target="_blank" >RIV/68407700:21230/25:00383339 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/25:10498378 RIV/00064165:_____/25:10498378

Result on the web

<a href="https://doi.org/10.1007/s00415-025-13070-8" target="_blank" >https://doi.org/10.1007/s00415-025-13070-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00415-025-13070-8" target="_blank" >10.1007/s00415-025-13070-8</a>

Result language

angličtina

Original language name

Long-term dopaminergic therapy improves spoken language in de-novo Parkinson's disease

Original language description

Background and objectivesThe impact of dopaminergic medication on language in Parkinson's disease (PD) remains poorly understood. This observational, naturalistic study aimed to investigate the effects of long-term dopaminergic therapy on language performance in patients with de-novo PD based on a high-level linguistic analysis of natural spontaneous discourse.MethodsA fairy-tale narration was recorded at baseline and a 12-month follow-up. The speech samples were automatically analyzed using six representative lexical and syntactic features based on automatic speech recognition and natural language processing.ResultsWe enrolled 109 de-novo PD patients compared to 68 healthy controls. All subjects completed the 12-month follow-up; 92 PD patients were on stable dopaminergic medication (PD-treated), while 17 PD patients remained without medication (PD-untreated). At baseline, the PD-treated group exhibited abnormalities in syntactic domains, particularly in sentence length (p = 0.018) and sentence development (p = 0.042) compared to healthy controls. After 12 months of dopaminergic therapy, PD-treated showed improvements in the syntactic domain, including sentence length (p = 0.012) and sentence development (p = 0.030). Of all PD-treated patients, 37 were on monotherapy with dopamine agonists and manifested improvement in sentence length (p = 0.048), while 32 were on monotherapy with levodopa and had no language amelioration. No changes in language parameters over time were seen in both the PD-untreated group and healthy controls.DiscussionInitiation of dopaminergic therapy improved high-language syntactic deficits in de-novo PD, confirming the role of dopamine in cognitive-linguistic processing. Automated linguistic analysis of spontaneous speech via natural language processing can assist in improving the prediction and management of language deficits in PD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neurology

ISSN

0340-5354

e-ISSN

1432-1459

Volume of the periodical

272

Issue of the periodical within the volume

5

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

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UT code for WoS article

001470230800004

EID of the result in the Scopus database

2-s2.0-105003705325