Automatic analysis of eyelid movement in de-novo Parkinson's disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F25%3A00383997" target="_blank" >RIV/68407700:21230/25:00383997 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10499947 RIV/00064165:_____/25:10499947
Result on the web
<a href="https://doi.org/10.1038/s41531-025-01021-z" target="_blank" >https://doi.org/10.1038/s41531-025-01021-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41531-025-01021-z" target="_blank" >10.1038/s41531-025-01021-z</a>

Result language
angličtina
Original language name
Automatic analysis of eyelid movement in de-novo Parkinson's disease
Original language description
This study presents an automated, objective method for eyelid movement assessment in de-novo Parkinson's disease(PD) using a one-dimensional camera setup during monologue. These measurements were related to Dopamine Transporter Single Photon Emission Tomography and clinical scores. State-of-the-art computer-vision technologies and deep-learning neural networks were utilized to measure fourteen eyelid movement markers describing blinking and eyelid kinematics. Video-recordings were collected from a total of 120 de-novo patients with PD and 55 healthy controls. Abnormal blinking was present in 38% of PD, indicated by a reduced blink rate (p < 0.001), an increased inter-blink interval (p < 0.001), and an increased rigidity of the palpebral aperture (p < 0.001). The classification experiment reached an area under the curve of 0.81 on a blinded test set. The blink rate correlated with the loss of nigral dopaminergic neurons (r = 0.35, p < 0.001). These findings suggest eyelid movement markers as strong reflections of striatal dopaminergic activity levels, underscoring the method's potential as a reliable early PD biomarker.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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