A thermodynamic model of bone remodelling: the influence of dynamic loading together with biochemical control

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F10%3A00170497" target="_blank" >RIV/68407700:21340/10:00170497 - isvavai.cz</a>

Alternative codes found

RIV/61388998:_____/10:00438609

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

A thermodynamic model of bone remodelling: the influence of dynamic loading together with biochemical control

Original language description

Understanding of the bone remodelling process has considerably increased during the last 20 years. The strength of the presented model is that it includes biochemical control factors (e.g., the necessity of cell-to-cell contact, which is mediated by theRANKL-RANK-OPG chain during osteoclastogenesis) and mechanical stimulation, the governing equations are derived from interaction kinetics, and the parameters are measurable. Behaviour of the model is in accordance with experimental and clinical observations, such as the role of dynamic loading, the inhibitory effect of dynamic loading on osteoclastogenesis, the observation that polykaryon osteoclasts are activated and formed by a direct cell-to-cell contact, and the correct concentrations of osteoblasts, osteoclasts, and osteocytes. The model does not yet describe the bone remodelling process in complete detail, but the implemented simplifications describe the key features and further details of control mechanisms may be added.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

<a href="/en/project/GA106%2F08%2F0557" target="_blank" >GA106/08/0557: Material properties of veins and their remodelling</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Musculoskeletal & Neuronal Interactions

ISSN

1108-7161

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

3

Country of publishing house

GR - GREECE

Number of pages

11

Pages from-to

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UT code for WoS article

000282051300005

EID of the result in the Scopus database

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