Preparation and Labelling Hydroxyapatite with 223Ra and 99mTc
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F15%3A00229691" target="_blank" >RIV/68407700:21340/15:00229691 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
slovinština
Original language name
Príprava a značenie hydroxyapatitov s 223Ra a 99mTc
Original language description
The aim of this study was the preparation, studies and investigation of novel nanoparticles suitable for targeted delivery of 223Ra and 99mTc. Preliminary experiments were focused on the synthesis of hydroxyapatite nanoparticles (HANPs) and their affinity to 223Ra and 99mTc. Technetium-99m (99mTc, T1/2 = 6.0 h) is the most commonly used medical radionuclide for diagnostic procedures. Radium?223 is the first ?-emitting radionuclide approved for targeted radionuclide therapy. The physical half-life of 223Ra of 11.4 days is providing sufficient time for the synthesis, distribution and administration of the radiopharmaceutical to patients. HANPs labelling yields with 223Ra were 95 - 100 % and with 99mTc were 93 ? 94 % depending on the reaction conditions.HANPs were studied on FT-IR (Fourier transform infrared spectroscopy), XRPD (X-Ray Powder Diffraction), DLS (Dynamic Light Scattering), and the sizes of nanoparticles were studied at temperatures 80, 120 and 200 °C.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CH - Nuclear and quantum chemistry, photo chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Zborník recenzovaných príspevkov - Študentská vedecká konferencia PriF UK 2015
ISBN
978-80-223-3859-2
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
1035-1040
Publisher name
Univerzita Komenského
Place of publication
Bratislava
Event location
Bratislava, SR
Event date
Apr 22, 2015
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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